founder sequences

The software tool "Founder Sequences" addresses a critical preprocessing step in pan-genomic analyses, focusing on efficiently representing aligned haplotype sequences of complete human chromosomes. Given the vast size of genomic data involved in these analyses, the primary goal of this tool is to condense the input set of sequences into a more manageable number of representative sequences without significant loss of genetic information. This process is crucial for simplifying subsequent analyses and making handling large genomic datasets feasible.

The improvement brought by "Founder Sequences" lies in its ability to process and represent thousands of complete human chromosomes efficiently. This task poses notable challenges due to the complexity and volume of the data. The tool's algorithmic advancements enable it to perform this reduction effectively, maintaining the integrity and diversity of the original genomic information while considerably reducing the dataset's size.

Topic

Detail

  • Operation: Genome indexing;Haplotype mapping

  • Software interface: Command-line interface

  • Language: C++

  • License: The MIT License

  • Cost: Free with restrictions

  • Version name: -

  • Credit: Academy of Finland.

  • Input: -

  • Output: -

  • Contact: Veli Mäkinen veli.makinen@helsinki.fi

  • Collection: -

  • Maturity: Stable

Publications

  • Linear time minimum segmentation enables scalable founder reconstruction.
  • Norri T, et al. Linear time minimum segmentation enables scalable founder reconstruction. Linear time minimum segmentation enables scalable founder reconstruction. 2019; 14:12. doi: 10.1186/s13015-019-0147-6
  • https://doi.org/10.1186/S13015-019-0147-6
  • PMID: 31131017
  • PMC: PMC6525415

Download and documentation


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